Translational Research Scientist

Mississauga, ON

Summary

Trillium Therapeutics is a clinical stage immuno-oncology company based in Cambridge, MA and Mississauga, ON. Following recent promising clinical data updates and after raising over $300 million in 2020, the Company is now embarking on a substantial organizational scale-up to initiate a phase 2 program across a range of cancer indications. The Company is seeking a highly motivated Translational Research Scientist to support development of existing and upcoming programs at Trillium. The position will report into the Director, Translational Research and will be based in Mississauga, Ontario.

The Company

Trillium Therapeutics (NASDAQ:TRIL) is a clinical stage biotechnology company developing next generation immunotherapies targeting CD47, a checkpoint of the innate immune system. Immunotherapy is a rapidly evolving field that is redefining cancer care by harnessing a patient’s own immune system to eliminate tumor cells. First generation immunotherapies, targeting the adaptive immune system via T cell checkpoint inhibitors, have been enormously successful scientifically (2018 Nobel Prize), clinically (achieving real cure rates), and commercially (soon to be the largest drug class ever). CD47 is now emerging as one of the most promising next generation immuno-oncology targets.

Trillium has two highly differentiated CD47 blockers in development that – unlike other CD47 agents – have shown unique monotherapy activity across a range of hematologic malignancies. Under new leadership, Trillium has undergone a wide-ranging transformation program, including a major strategy reset. In 2020, the company raised over $300M, landed a strategic investment from Pfizer, and has been among the top performers on NASDAQ. Nearing completion of ongoing dose escalation studies, Trillium is now scaling up its organization to initiate a broad phase 2 program across several cancer indications.

The Position

The Translational Research Scientist supports development of existing and upcoming programs at Trillium, by conducting in-depth research projects as assigned by the Group Leader.

Essential Accountabilities

  • Supervise daily activities of Research Associates in clinical immune phenotyping/functional assays:
    • Design, plan and prioritize research activities and schedules.
    • Provide technical guidance and troubleshooting assistance.
    • Provide back-up support to all research and lab activities.
  • Lead pre-clinical/non-clinical research studies:
    • Design and execute biochemical and cell biology experiments to support the development of Trillium pipeline portfolio.
    • Coordinate and manage outsourced in vitro/in vivo studies with CROs and academic research labs.
    • Analyze research data and prepare study reports.
  • Development of new assays for existing and upcoming clinical trials:
    • Plan and execute assay development.
    • Prepare study summaries.
  • Analyze data from clinical PD/biomarker and other exploratory research assays:
    • Prepare study summaries and reports.
    • Provide updates to Group Leader.
  • Present data at internal and external meetings:
    • Prepare study summaries, posters, manuscripts.
    • Act as Subject Matter Expert for clinical trials as assigned.
  • Stay abreast of the relevant literature in immuno-oncology and clinical biomarkers.
  • Adhere to laboratory safety standards, including proper handling of hazardous materials and waste.
  • Other duties as required.
  • Work in compliance with the Trillium’s Code of Business Conduct and Ethics and all workplace policies, procedures and regulations.

Qualifications

  • PhD in immunology preferred plus relevant post-doctoral experience. 4+ years industry or post-doc experience preferred. Industry experience is an asset.
  • Extensive experience with design, execution and analysis of assays incorporating tissue culture and primary cells, including, but not limited to: multi-parameter flow cytometry, immune-related functional assays (ELISPOT, T cell activation assays, ADCC and ADCP assays) and proliferation assays.
  • The Translational Scientist will be expected to work in a BSL2 laboratory up to 50% of the time. Human blood and tissues are used. Hours are variable depending on sampling and assay requirements and occasional night/weekend work is required.
  • Extensive computer work is required.
  • Highly proficient in MS Office Suite (Word, Excel, PowerPoint, MS Project, MS Access), FlowJo and Prism Graphpad.
  • Ability to work in Biological Safety cabinet and at laboratory bench, lift lab equipment/reagents (up to 30lb).

Personal Attributes

  • Strong values-driven individual able to function in a diverse, cross-functional and multi-disciplinary team.
  • Must be willing and able to be “hands-on,” and thrive in a matrixed, fast-paced, dynamic and changing business environment.
  • Strong interpersonal and leadership skills, and willingness to collaborate with others on assigned projects (including both internal teams and external parties).
  • Keen attention to detail and demonstrated ability to multitask.
  • Strong written and oral communication skills.
  • Critical and analytical thinker.
  • Highly versatile with ability to swiftly shift focus while attending to multiple competing priorities.

How to Apply

Please send your resume and cover letter to careers@trilliumtherapeutics.com with the title of the role in the subject line. Kindly note that phone calls and third parties are not accepted.

We thank all applicants for their interest. We will be reaching out only to candidates whose backgrounds most closely match our needs.