Senior Director, Commercial Strategy

Cambridge, MA


Trillium Therapeutics is a clinical stage immuno-oncology company based in Cambridge, MA and Toronto, ON. Following recent promising clinical data updates and after raising over $300 million in 2020, the Company has embarked on a substantial organizational scale-up and initiated an ambitious phase 1b/2 program across a range of cancer indications. The Company is seeking a new Senior Director of Commercial Strategy, who will play a leadership role in Trillium’s clinical strategy and operational activities. The position will report into the SVP, Corporate Development and Strategy, and will be based in Cambridge, MA.

The Company

Trillium Therapeutics (Nasdaq:TRIL) is a clinical stage biotechnology company developing next generation immunotherapies targeting CD47, a checkpoint of the innate immune system. Immunotherapy is a rapidly evolving field that is redefining cancer care by harnessing a patient’s own immune system to eliminate tumor cells. First generation immunotherapies, targeting the adaptive immune system via T cell checkpoint inhibitors, have been enormously successful scientifically (2018 Nobel prize), clinically (achieving real cure rates), and commercially (soon to be the largest drug class ever). CD47 is now emerging as one of the most promising next generation immuno-oncology targets.

Trillium has two highly differentiated CD47 blockers in development that – unlike other CD47 agents – have shown unique monotherapy activity across a range of hematologic malignancies. Under new leadership, Trillium has undergone a wide-ranging transformation program, including a major strategy reset. In 2020, the company raised over $300M and secured a strategic investment from Pfizer. After initiating an ambitious Phase 1b/2 program across multiple hematologic and solid tumor indications earlier this year, Trillium is now scaling up its organization to ensure strong execution of the program.


  • In partnership with the Executive Team, lead ongoing evolution and refinement of program commercial strategies and target product profiles.
  • Lead new indication expansion efforts, as well as resource allocation and trade-off considerations
  • Actively source and lead external collaborations that align with Trillium’s strategic priorities and serve as an alliance’s single point of contact.
  • Partner closely with cross-functional program teams, providing commercial input to program governance.
  • Work closely with leaders across Trillium on strategic initiatives, as required, to ensure alignment with overall program plans.
  • Support communications for corporate updates, investor relation events, and other external presentations.
  • Work in compliance with Trillium’s Code of Business Conduct and all workplace policies, procedures, and regulations.


  • Bachelor’s degree in science; Advanced scientific degree (MD, PhD, PharmD) strongly preferred.
  • Minimum 10 years related work experience in R&D with excellent drug development knowledge; understanding of the Oncology therapeutic area required.
  • Exceptional matrix and situational leadership skills with experience leading multi-disciplinary teams of functional experts.
  • Ability to rapidly synthesize information from multiple sources, communicate ideas and data both verbally and written format for a variety of audiences.
  • Ability to create and communicate key presentations to internal leadership and external partners with credibility and confidence.

Personal Attributes

  • Able to work across many interfaces (clinical/clinical operations, CMC, investor relations, project management, etc.).
  • Demonstrated strong interpersonal skills, ability to influence, and the ability to function in a global team environment.
  • Thrives in an ambiguous environment with a constant focus on delivering results.
  • Strong and effective communication skills (written and verbal), with excellent medical/scientific writing skills.
  • Strong integrity and a commitment to improving patient outcomes.
  • Must be willing and able to be “hands-on”, and can thrive in a matrixed, fast-paced business environment.
  • Ability to work effectively with other company leaders and develop strong working relationships with them.
  • Once routine travel resumes, willingness and ability to travel up to 30% of time.

The duties and responsibilities contained in the job description are not exhaustive and may be changed by the Company at any time.

How to Apply

Please send your resume and cover letter to with the title of the role in the subject line. Kindly note that phone calls and third parties are not accepted.

We thank all applicants for their interest. We will be reaching out only to candidates whose backgrounds most closely match our needs.