Project Manager


Trillium Therapeutics is a clinical stage immuno-oncology company based in Cambridge, MA and Toronto, ON. Following recent promising clinical data updates and after raising over $300 million in 2020, the Company has embarked on a substantial organizational scale-up and initiated an ambitious phase 1b/2 program across a range of cancer indications. The Company is seeking a Project Manager who will report to the VP, Clinical Operations. This individual will be responsible for delivering cross-functional project management excellence to clinical stage programs up to registration and commercialization. The successful candidate is expected to apply project management best practices to facilitate the development and execution of integrated project plans and deliverables for cross-functional drug development teams. The ideal candidate will have a scientific or business background and experience with clinical-stage drug development.

The position will (preferentially) be based in Cambridge, MA or in Mississauga, ON, Canada.

The Company

Trillium Therapeutics (Nasdaq:TRIL) is a clinical stage biotechnology company developing next generation immunotherapies targeting CD47, a checkpoint of the innate immune system. Immunotherapy is a rapidly evolving field that is redefining cancer care by harnessing a patient’s own immune system to eliminate tumor cells. First generation immunotherapies, targeting the adaptive immune system via T cell checkpoint inhibitors, have been enormously successful scientifically (2018 Nobel prize), clinically (achieving real cure rates), and commercially (soon to be the largest drug class ever). CD47 is now emerging as one of the most promising next generation immuno-oncology targets.

Trillium has two highly differentiated CD47 blockers in development that – unlike other CD47 agents – have shown unique monotherapy activity across a range of hematologic malignancies. Under new leadership, Trillium has undergone a wide-ranging transformation program, including a major strategy reset. In 2020, the company raised over $300M and secured a strategic investment from Pfizer. After initiating an ambitious Phase 1b/2 program across multiple hematologic and solid tumor indications earlier this year, Trillium is now scaling up its organization to ensure strong execution of the program.


  • Work with team members of one or more program teams to compile high-quality, detailed, integrated cross-functional program plans, manage program activities, timelines, and resources.
  • Provide active meeting management by publishing agendas, assembling pre-reads, capturing minutes, and tracking action items.
  • Work with the program leader(s) to facilitate cross-functional decision making and resolve conflicts; proactively identify key risks, timeline and resource constraints, and develop mitigation plans.
  • Support the program leader(s) to establish, track, and monitor performance metrics and project status.
  • Together with the program leader(s), ensure communication between program teams and subteams as well as communication between program teams for shared resources.
  • Work closely with finance team to support program budget tracking and facilitate approval of changes that arise throughout the year due to changing conditions/plans within the program.


  • Bachelor’s degree in science, business or equivalent. Advanced degree preferred.
  • 5+ years of relevant biotech and pharmaceutical industry experience managing cross-functional teams, with broad knowledge across all facets of drug development. Experience with managing clinical stage programs is required.
  • Demonstrated understanding of project management principles, best practices, tools, technology and methods. Advanced project management certification (PgMP, PMP) is desirable.
  • In-depth knowledge of pharmaceutical drug discovery and development in oncology.
  • Proficient with MS Office (Word, Excel, PowerPoint) and managing Teams & SharePoint platforms. Experience managing project schedules using Microsoft Project or similar software.

Personal Attributes

  • Self-directed, accomplishment-driven individual with a strong sense of passion and urgency who can work both independently and in a cross-functional team environment.
  • Able to work across many interfaces (clinical development, regulatory affairs, clinical operations, translational, non-clinical, finance).
  • Experience in a fast-paced environment required; must be willing and able to be “hands-on” with a strong sense of accountability.
  • Close attention to details, innovative problem solving and excellent organizational skills.
  • Demonstrated success with handling multiple projects and able to handle complexity and prioritize effectively.
  • Strong and effective communication skills (written and verbal).
  • Must be pro-active collaborator, flexible, and open to change.
  • Some travel maybe required, up to 30%.

The duties and responsibilities contained in the job description are not exhaustive and may be changed by the Company at any time.

How to Apply

Please send your resume and cover letter to with the title of the role in the subject line. Kindly note that phone calls and third parties are not accepted.

We thank all applicants for their interest. We will be reaching out only to candidates whose backgrounds most closely match our needs.